The MatP/matS Site-Specific System Organizes the Terminus Region of the E. coli Chromosome into a Macrodomain

@article{Mercier2008TheMS,
  title={The MatP/matS Site-Specific System Organizes the Terminus Region of the E. coli Chromosome into a Macrodomain},
  author={R. Mercier and M. Petit and S. Schbath and S. Robin and M. Karoui and F. Boccard and O. Esp{\'e}li},
  journal={Cell},
  year={2008},
  volume={135},
  pages={475-485}
}
  • R. Mercier, M. Petit, +4 authors O. Espéli
  • Published 2008
  • Biology, Medicine
  • Cell
  • The organization of the Escherichia coli chromosome into insulated macrodomains influences the segregation of sister chromatids and the mobility of chromosomal DNA. Here, we report that organization of the Terminus region (Ter) into a macrodomain relies on the presence of a 13 bp motif called matS repeated 23 times in the 800-kb-long domain. matS sites are the main targets in the E. coli chromosome of a newly identified protein designated MatP. MatP accumulates in the cell as a discrete focus… CONTINUE READING
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