The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release.

@article{Gottwein2003TheMM,
  title={The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release.},
  author={Eva Gottwein and Jochen Bodem and Barbara M{\"u}ller and Ariane Schmechel and H. Zentgraf and Hans-Georg Kr{\"a}usslich},
  journal={Journal of virology},
  year={2003},
  volume={77 17},
  pages={
          9474-85
        }
}
Late (L) domains are required for the efficient release of several groups of enveloped viruses. Three amino acid motifs have been shown to provide L-domain function, namely, PPXY, PT/SAP, or YPDL. The retrovirus Mason-Pfizer monkey virus (MPMV) carries closely spaced PPPY and PSAP motifs. Mutation of the PPPY motif results in a complete loss of virus release. Here, we show that the PSAP motif acts as an additional L domain and promotes the efficient release of MPMV but requires an intact PPPY… CONTINUE READING
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