The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders.

Abstract

Many, if not all, chronic medical, neurodegenerative and neuroprogressive illnesses are characterised by chronic immune activation, oxidative and nitrosative stress (O&NS) and systemic inflammation. These factors, notably elevated pro-inflammatory cytokines, activate indoleamine 2,3-dioxygenase (IDO) leading to an upregulated tryptophan catabolite (TRYCAT… (More)

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Cite this paper

@article{Morris2016TheMN, title={The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders.}, author={Gerwyn Morris and Andr{\'e} Carlos Ponce de Leon Ferreira de Carvalho and George Anderson and Piotr Gaļecki and Michael Maes}, journal={Current pharmaceutical design}, year={2016}, volume={22 8}, pages={963-77} }