The Mammary Gland: A Model for Development

@article{Daniel2004TheMG,
  title={The Mammary Gland: A Model for Development},
  author={C. Daniel and Gilbert H. Smith},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2004},
  volume={4},
  pages={3-8}
}
questions with broad biological implications for the Hennighausen and colleagues, in a recent review development of many organs and tissues in a variety (1) cite evidence that more than 8,300 publications on of organisms. Much of the emergence of the mammary the development and secretions of the mammary gland gland as a model system is due to powerful experimenhad been published by 1899. The term a development,o tal techniques that are uniquely available to pracwhen used in reference to mammary… Expand
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  • Journal of Mammary Gland Biology and Neoplasia
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Some unique properties of the mammary gland are illustrated which provide the basis for specialized approaches to developmental, neoplastic, and functional problems. Expand
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On a phylogenetic scale of organ development the mammary gland is a recent acquisition. It was introduced 200 million years ago with the appearance of mammals to provide nourishment to the newborn inExpand
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Together, these results indicate that progesterone acts by a paracrine mechanism on a subset of mammary epithelial cells to allow for alveolar growth and that expression of the PR is not required in all the cells of the Mammary epithelium in order forAlveolar development to proceed normally. Expand
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The results suggest that Wnt-10b, or other Wnt genes expressed early in mammary development, play a role in regulating sexual dimorphism and show potent transforming activity when overexpressed. Expand
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Hox expression was studied in mammary adenocarcinomas and in transplant lines of the benign, precancerous tissues from which the cancers arose, suggesting that Hox genes may play a role in a late stage in the stepwise development of mammary malignancies. Expand
Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development.
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Results suggest that PTHrP, which is a native product of mammary epithelial and myoepithelial cells, may participate in normal breast development, perhaps as a locally secreted growth inhibitor. Expand
Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.
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The pattern of defects suggest an essential role for LEF-1 in the formation of several organs and structures that require inductive tissue interactions in mice carrying a homozygous germ-line mutation in the LEf-1 gene. Expand
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