The Mammary Gland: A Model for Development

  title={The Mammary Gland: A Model for Development},
  author={Charles W. Daniel and Gilbert H. Smith},
  journal={Journal of Mammary Gland Biology and Neoplasia},
questions with broad biological implications for the Hennighausen and colleagues, in a recent review development of many organs and tissues in a variety (1) cite evidence that more than 8,300 publications on of organisms. Much of the emergence of the mammary the development and secretions of the mammary gland gland as a model system is due to powerful experimenhad been published by 1899. The term a development,o tal techniques that are uniquely available to pracwhen used in reference to mammary… 

Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development

Current research on the biology of normal mammary stem cells with an emphasis on properties of cellular plasticity, self-renewal and quiescence, as well as the role of the microenvironment in regulating these processes are focused on.

Overview of Mammary Gland Development: A Comparison of Mouse and Human.

The parallels and contrasts in mouse mammary gland and human breast morphogenesis from an early embryonic phase through to puberty, adulthood, pregnancy, parturition, and lactation, and finally the regressive stage of involution are described.

Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation.

This review describes how mouse embryonic mammogenesis depends on a continuous communication between the epithelial and mesenchymal compartment of the mammary rudiment and suggests that different molecular mechanisms may underlie the formation of such identical structures.

The Mammary Gland: Basic Structure and Molecular Signaling during Development

The mammary gland is a compound, branched tubuloalveolar structure and a major characteristic of mammals. The mammary gland has evolved from epidermal apocrine glands, the skin glands as an accessory

The Terminal End Bud: the Little Engine that Could

The current understanding of TEB biology is summarized, areas of future study are discussed, and the use of the TEB as a model for the study of breast cancer is discussed.

Generation of a functional mammary gland from a single stem cell

It is shown that a single cell, marked with a LacZ transgene, can reconstitute a complete mammary gland in vivo and establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs.

Stem Cells and the Differentiation Hierarchy in Mammary Gland Development.

The emerging diversity amongst stem and progenitor populations of the mammary epithelium is likely to underpin the heterogeneity that characterizes breast cancer.

PER2 regulation of mammary gland development

A crucial noncircadian function of PER2 is revealed in mammalian mammary gland development, validates the Per2−/− model, and describes a potential role for PER2 in breast cancer is described.

p190-B RhoGAP regulates mammary ductal morphogenesis.

The results suggest that p190-B regulates ductal morphogenesis, at least in part, by modulating the IGF signaling axis.



The mammary gland: A unique organ for the study of development and tumorigenesis

  • D. Medina
  • Medicine
    Journal of Mammary Gland Biology and Neoplasia
  • 2005
Some unique properties of the mammary gland are illustrated which provide the basis for specialized approaches to developmental, neoplastic, and functional problems.

Think globally, act locally: the making of a mouse mammary gland.

On a phylogenetic scale of organ development the mammary gland is a recent acquisition. It was introduced 200 million years ago with the appearance of mammals to provide nourishment to the newborn in

A paracrine role for the epithelial progesterone receptor in mammary gland development.

Together, these results indicate that progesterone acts by a paracrine mechanism on a subset of mammary epithelial cells to allow for alveolar growth and that expression of the PR is not required in all the cells of the Mammary epithelium in order forAlveolar development to proceed normally.

Prolactin Signaling in Mammary Gland Development*

Although Stat5a is in the line of fire of many signals such as PRL, growth hormone (GH), and several cytokines, its absence in vivo reveals an unexpected level of specificity.

Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice

The results suggest that Wnt-10b, or other Wnt genes expressed early in mammary development, play a role in regulating sexual dimorphism and show potent transforming activity when overexpressed.

Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.

It is demonstrated that PTHrP plays a critical role in the epithelial-mesenchymal communications that guide the initial round of branching morphogenesis that occurs during the embryonic development of the mammary gland.

Hox genes in normal and neoplastic mouse mammary gland.

Hox expression was studied in mammary adenocarcinomas and in transplant lines of the benign, precancerous tissues from which the cancers arose, suggesting that Hox genes may play a role in a late stage in the stepwise development of mammary malignancies.

Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development.

Results suggest that PTHrP, which is a native product of mammary epithelial and myoepithelial cells, may participate in normal breast development, perhaps as a locally secreted growth inhibitor.

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

The pattern of defects suggest an essential role for LEF-1 in the formation of several organs and structures that require inductive tissue interactions in mice carrying a homozygous germ-line mutation in the LEf-1 gene.