The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration

@article{Cartoni2016TheMP,
  title={The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration},
  author={Romain Cartoni and Michael W. Norsworthy and Fengfeng Bei and Chen Wang and Siwei Li and Yiling Zhang and Christopher V Gabel and Thomas L Schwarz and Zhigang He},
  journal={Neuron},
  year={2016},
  volume={92},
  pages={1294-1307}
}
Mitochondrial transport is crucial for neuronal and axonal physiology. However, whether and how it impacts neuronal injury responses, such as neuronal survival and axon regeneration, remain largely unknown. In an established mouse model with robust axon regeneration, we show that Armcx1, a mammalian-specific gene encoding a mitochondria-localized protein, is upregulated after axotomy in this high regeneration condition. Armcx1 overexpression enhances mitochondrial transport in adult retinal… CONTINUE READING

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