2,029 Citations
Sequencing the Epigenome
- Biology
- 2009
New applications of ultra high-throughput sequencing has improved the precision, comprehensiveness and throughput of techniques for mapping chromatin and DNA methylation and their use for high resolution interrogation of mammalian epigenomes is focused on.
Editing the Epigenome: Reshaping the Genomic Landscape.
- BiologyAnnual review of genomics and human genetics
- 2018
Genome engineering technologies use highly specific DNA-targeting tools to precisely deposit epigenetic changes in a locus-specific manner, creating diverse epigenome editing platforms, including applications for translational purposes, such as epigenetic therapy and regenerative medicine.
Environmental Impact on Epigenetic Histone Language
- Biology
- 2013
This chapter explores the idea of a histone language written within the combinatorial complexity of PTMs, and discusses targeting the epigenome as a new paradigm for drug development.
Epigenetics: Tools and Technologies.
- BiologyDrug discovery today. Technologies
- 2010
The state of chromatin, the complex of histone proteins, RNA and DNA that efficiently package the genome, is largely regulated by specific modifications to hist one proteins and DNA, and the recognition of these marks by other proteins and protein complexes.
Linking genome to epigenome
- BiologyWiley interdisciplinary reviews. Systems biology and medicine
- 2012
A number of recent studies strongly suggest that the sequence information is important not just for controlling target specificity but for orchestrating the diversity of epigenetic patterns among different cell types.
Charting histone modifications and the functional organization of mammalian genomes
- BiologyNature Reviews Genetics
- 2011
A selection of recent studies that have probed histone modifications and successive layers of chromatin structure in mammalian genomes, the patterns that have been identified and future directions for research are reviewed.
Chromatin proteomics and epigenetic regulatory circuits
- BiologyExpert review of proteomics
- 2008
The evidence to date implies the importance of an interplay of all these chromatin-changing functions, generating an epigenetic regulatory circuit that is still not well understood.
Epigenomic profiling of cancer cells.
- BiologyThe international journal of biochemistry & cell biology
- 2009
References
SHOWING 1-10 OF 106 REFERENCES
Strategies for dissecting epigenetic mechanisms in the mouse
- BiologyNature Genetics
- 2005
Current approaches and protocols used to study epigenetics in the mouse are discussed, including loss-of-function studies, mutagenesis screens, somatic cell nuclear transfer, genomics and proteomics.
Epigenomics: beyond CpG islands
- BiologyNature Reviews Genetics
- 2004
The statistical solutions that help to overcome the problems with data-set complexity are described, in anticipation of the imminent wealth of data that will be generated by new genome-wide epigenetic profiling and DNA sequence analysis techniques.
Translating the Histone Code
- BiologyScience
- 2001
It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Heterochromatin and Epigenetic Control of Gene Expression
- BiologyScience
- 2003
An unexpected role for noncoding RNAs and RNA interference in the formation of epigenetic chromatin domains has been uncovered.
The fundamental role of epigenetic events in cancer
- BiologyNature Reviews Genetics
- 2002
This review discusses patterns of DNA methylation and chromatin structure in neoplasia and the molecular alterations that might cause them and/or underlie altered gene expression in cancer.
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote.
- BiologyGenes & development
- 2004
A genome-wide chromatin structure analysis in a higher eukaryote found a binary pattern of histone modifications among euchromatic genes, with active genes being hyperacetylated for H3 and H4 and hypermethylated at Lys 4 and Lys 79 of H3, and inactive genes being hypomethylated and deacetylation at the same residues.
A blueprint for a Human Epigenome Project: the AACR Human Epigenome Workshop.
- BiologyCancer research
- 2005
A timely workshop of leading experts confirmed that the technology is at hand to begin defining human epigenomes at high resolution.
Genome-scale profiling of histone H3.3 replacement patterns
- BiologyNature Genetics
- 2005
It is proposed that deposition and inheritance of actively modified H3.3 in regulatory regions maintains transcriptionally active chromatin and is introduced a new strategy for profiling epigenetic patterns on the basis of H 3.3 replacement.
Epigenetics: Unfinished symphony
- BiologyNature
- 2006
A global effort to decode the epigenetic code, which refers to all the heritable biological factors other than DNA sequence that influence gene expression, is now in the making.