The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution

@inproceedings{Agrawal2014TheMG,
  title={The Major
G-Quadruplex Formed in the Human
BCL-2 Proximal Promoter Adopts a Parallel Structure with a
13-nt Loop in K+ Solution},
  author={Prashansa Agrawal and Clement Lin and Raveendra I. Mathad and Megan Carver and Danzhou Yang},
  booktitle={Journal of the American Chemical Society},
  year={2014}
}
The human BCL-2 gene contains a 39-bp GC-rich region upstream of the P1 promoter that has been shown to be critically involved in the regulation of BCL-2 gene expression. Inhibition of BCL-2 expression can decrease cellular proliferation and enhance the efficacy of chemotherapy. Here we report the major G-quadruplex formed in the Pu39 G-rich strand in this BCL-2 promoter region. The 1245G4 quadruplex adopts a parallel structure with one 13-nt and two 1-nt chain-reversal loops. The 1245G4… CONTINUE READING