The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes

@article{Luijsterburg2008TheMA,
  title={The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes},
  author={Martijn S. Luijsterburg and Malcolm F. White and Roel van Driel and Remus T. Dame},
  journal={Critical Reviews in Biochemistry and Molecular Biology},
  year={2008},
  volume={43},
  pages={393 - 418}
}
The genomic DNA of all organisms across the three kingdoms of life needs to be compacted and functionally organized. Key players in these processes are DNA supercoiling, macromolecular crowding and architectural proteins that shape DNA by binding to it. The architectural proteins in bacteria, archaea and eukaryotes generally do not exhibit sequence or structural conservation especially across kingdoms. Instead, we propose that they are functionally conserved. Most of these proteins can be… 
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84 Citations

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This review provides an alternative and/or complementary perspective to the traditional views on bacterial nucleoid compaction and expansion as other recent comprehensive reviews have dealt with the roles of other factors inacterial nucleoid organization.
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It is shown that S so10a1 and Sso10a2 exhibit different distinct DNA-binding modes, which can be exploited to drive changes in local genome folding, which may operate to modulate transcription.
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The hierarchical nature of bacterial chromosome structure and how it is influenced by diverse types of nucleoid-associated proteins is discussed, including in gene expression, chromosome segregation and cell cycle regulation.
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TLDR
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