The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes

  title={The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes},
  author={M. S. Luijsterburg and Malcolm F. White and R. VAN Driel and R. T. Dame},
  journal={Critical Reviews in Biochemistry and Molecular Biology},
  pages={393 - 418}
  • M. S. Luijsterburg, Malcolm F. White, +1 author R. T. Dame
  • Published 2008
  • Biology
  • Critical Reviews in Biochemistry and Molecular Biology
  • The genomic DNA of all organisms across the three kingdoms of life needs to be compacted and functionally organized. Key players in these processes are DNA supercoiling, macromolecular crowding and architectural proteins that shape DNA by binding to it. The architectural proteins in bacteria, archaea and eukaryotes generally do not exhibit sequence or structural conservation especially across kingdoms. Instead, we propose that they are functionally conserved. Most of these proteins can be… CONTINUE READING
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