The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.

@article{Bieri2017TheMT,
  title={The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.},
  author={Raphael Bieri and Nicole Scherr and Mischa Ruf and Jean-Pierre Dangy and Philipp Rolf Gersbach and Matthias Gehringer and Karl-Heinz Altmann and Gerd Pluschke},
  journal={ACS chemical biology},
  year={2017},
  volume={12 5},
  pages={
          1297-1307
        }
}
Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, is central to the pathogenesis of the chronic necrotizing skin disease Buruli ulcer (BU). Here we show that mycolactone acts as an inhibitor of the mechanistic Target of Rapamycin (mTOR) signaling pathway by interfering with the assembly of the two distinct mTOR protein complexes mTORC1 and mTORC2, which regulate different cellular processes. Inhibition of the assembly of the rictor containing mTORC2 complex by mycolactone… CONTINUE READING
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