The MRX complex regulates Exo1 resection activity by altering DNA end structure.

@article{Gobbini2018TheMC,
  title={The MRX complex regulates Exo1 resection activity by altering DNA end structure.},
  author={Elisa Gobbini and Corinne Cassani and Jacopo Vertemara and Weibin Wang and Fabiana Mambretti and Erika Casari and Patrick Sung and Renata Tisi and Giuseppe Zampella and Maria Pia Longhese},
  journal={The EMBO journal},
  year={2018},
  volume={37 16}
}
Homologous recombination is triggered by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs). DSB resection requires the Mre11-Rad50-Xrs2 (MRX) complex, which promotes the activity of Exo1 nuclease through a poorly understood mechanism. Here, we describe the Mre11-R10T mutant variant that accelerates DSB resection compared to wild-type Mre11 by potentiating Exo1-mediated processing. This increased Exo1 resection activity leads to a decreased association of the Ku complex to… CONTINUE READING
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