The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

@article{DAmours2002TheMC,
  title={The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling},
  author={Damien D'Amours and Stephen P. Jackson},
  journal={Nature Reviews Molecular Cell Biology},
  year={2002},
  volume={3},
  pages={317-327}
}
The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA- damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication. 
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