The MPS1 family of protein kinases.

  title={The MPS1 family of protein kinases.},
  author={Xuedong Liu and Mark Winey},
  journal={Annual review of biochemistry},
MPS1 protein kinases are found widely, but not ubiquitously, in eukaryotes. This family of potentially dual-specific protein kinases is among several that regulate a number of steps of mitosis. The most widely conserved MPS1 kinase functions involve activities at the kinetochore in both the chromosome attachment and the spindle checkpoint. MPS1 kinases also function at centrosomes. Beyond mitosis, MPS1 kinases have been implicated in development, cytokinesis, and several different signaling… CONTINUE READING
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