The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing.

@article{Kang2009TheMG,
  title={The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing.},
  author={Y Kang and Min-Jung Kang and Jeong-Hoon Kim and Chul-Hwan Lee and Il-Taeg Cho and Jerard Hurwitz and Y Seo},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 16},
  pages={10376-86}
}
Saccharomyces cerevisiae MPH1 was first identified as a gene encoding a 3' to 5' DNA helicase, which when deleted leads to a mutator phenotype. In this study, we isolated MPH1 as a multicopy suppressor of the dna2K1080E helicase-negative lethal mutant. Purified Mph1 stimulated the endonuclease activities of both Fen1 and Dna2, which act faithfully in the… CONTINUE READING