The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

@article{Fesquet1993TheMG,
  title={The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.},
  author={Didier Fesquet and J-C. Labb{\'e} and Jean Derancourt and J. P. Capony and Simon Galas and Franck Girard and Thierry Lorca and John Shuttleworth and Marcel Dor{\'e}e and Jean-claude Cavadore},
  journal={The EMBO journal},
  year={1993},
  volume={12 8},
  pages={3111-21}
}
Phosphorylation of Thr161, a residue conserved in all members of the cdc2 family, has been reported to be absolutely required for the catalytic activity of cdc2, the major regulator of eukaryotic cell cycle. In the present work, we have purified from starfish oocytes a kinase that specifically activates cdc2 in a cyclin-dependent manner through phosphorylation of its Thr161 residue. Our most highly purified preparation contained only two major proteins of apparent M(r) 37 and 40 kDa (p37 and… CONTINUE READING
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