The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence.

@article{MeesterSmoor2007TheMO,
  title={The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence.},
  author={Magda A. Meester-Smoor and Anco C Molijn and Yixian Zhao and Nicole A. Groen and Cora A H Groffen and Merel W Boogaard and Diny van Dalsum-Verbiest and Gerard C. Grosveld and Ellen C. Zwarthoff},
  journal={Journal of molecular endocrinology},
  year={2007},
  volume={38 1-2},
  pages={113-25}
}
The IGF-binding protein (IGFBP) family consists of six proteins that are expressed and secreted in different tissues. The proteins are regulators of physiological processes throughout the body by modulating the activity of IGF-I and IGF-II. In this article, we describe the coordinated expression of IGFBP5 and MN1 in meningiomas. MN1 is a transcriptional co-activator and we show that MN1 stimulates the IGFBP5 promoter in Hep3B cells. A CACCC-containing sequence, located 140 bp upstream of the… CONTINUE READING
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