The MLL recombinome of acute leukemias

@article{Meyer2006TheMR,
  title={The MLL recombinome of acute leukemias},
  author={C. Meyer and B. Schneider and S. Jakob and S. Strehl and A. Attarbaschi and S. Schnittger and C. Schoch and M. Jansen and J. V. Dongen and M. D. Boer and R. Pieters and M. Ennas and E. Angelucci and U. Koehl and J. Greil and F. Griesinger and U. Stadt and C. Eckert and T. Szczepański and F. Niggli and B. Sch{\"a}fer and H. Kempski and H. Brady and J. Zuna and J. Trka and L. L. Nigro and A. Biondi and E. Delabesse and E. Macintyre and M. Stanulla and M. Schrappe and O. Haas and T. Burmeister and T. Dingermann and T. Klingebiel and R. Marschalek},
  journal={Leukemia},
  year={2006},
  volume={20},
  pages={777-784}
}
Chromosomal rearrangements of the human MLL gene are a hallmark for aggressive (high-risk) pediatric, adult and therapy-associated acute leukemias. These patients need to be identified in order to subject these patients to appropriate therapy regimen. A recently developed long-distance inverse PCR method was applied to genomic DNA isolated from individual acute leukemia patients in order to identify chromosomal rearrangements of the human MLL gene. We present data of the molecular… Expand
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