The MLL/Setd1b methyltransferase is required for the Spemann's organizer gene activation in Xenopus

Abstract

Wdr5 is an essential component of SET/MLL methylase complexes that catalyze histone H3 lysine 4 trimethylation. The maternal Wnt/β-catenin signaling is necessary for the H3K4me3 deposition at organizer genes in early Xenopus embryos. However, it remains unknown whether any component of SET/MLL methylase complex is required for Wnt signaling to establish… (More)
DOI: 10.1016/j.mod.2016.08.002

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