The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis.

@article{Kress2011TheMK,
  title={The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis.},
  author={Theresia R. Kress and Ian G. Cannell and Arjan B. Brenkman and Birgit Samans and Matthias Gaestel and Paul Roepman and Boudewijn M T Burgering and Martin Bushell and Andreas Rosenwald and Martin Eilers},
  journal={Molecular cell},
  year={2011},
  volume={41 4},
  pages={445-57}
}
Expression of the Myc oncoprotein is downregulated in response to stress signals to allow cells to cease proliferation and escape apoptosis, but the mechanisms involved in this process are poorly understood. Cell cycle arrest in response to DNA damage requires downregulation of Myc via a p53-independent signaling pathway. Here we have used siRNA screening… CONTINUE READING