The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.

@article{Row2007TheMD,
  title={The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.},
  author={Paula E. Row and Han Liu and Sebastian Hayes and Rebecca L. Welchman and Panagoula Charalabous and Kay Hofmann and Michael J Clague and Christopher M. Sanderson and Sylvie Urb{\'e}},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 42},
  pages={30929-37}
}
We have identified and characterized a Microtubule Interacting and Transport (MIT) domain at the N terminus of the deubiquitinating enzyme UBPY/USP8. In common with other MIT-containing proteins such as AMSH and VPS4, UBPY can interact with CHMP proteins, which are known to regulate endosomal sorting of ubiquitinated receptors. Comparison of binding… CONTINUE READING