The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.

@article{Row2007TheMD,
  title={The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.},
  author={Paula E. Row and Han Liu and Sebastian Hayes and Rebecca L. Welchman and Panagoula Charalabous and Kay Hofmann and Michael J Clague and Christopher M. Sanderson and Sylvie Urb{\'e}},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 42},
  pages={
          30929-37
        }
}
We have identified and characterized a Microtubule Interacting and Transport (MIT) domain at the N terminus of the deubiquitinating enzyme UBPY/USP8. In common with other MIT-containing proteins such as AMSH and VPS4, UBPY can interact with CHMP proteins, which are known to regulate endosomal sorting of ubiquitinated receptors. Comparison of binding preferences for the 11 members of the human CHMP family between the UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common… CONTINUE READING

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