The MIF homologue D-dopachrome tautomerase promotes COX-2 expression through β-catenin-dependent and -independent mechanisms.

@article{Xin2010TheMH,
  title={The MIF homologue D-dopachrome tautomerase promotes COX-2 expression through β-catenin-dependent and -independent mechanisms.},
  author={Dan Xin and Beatriz E. Rendon and Mingming Zhao and Millicent G Winner and Arlixer McGhee Coleman and Robert Mitchell},
  journal={Molecular cancer research : MCR},
  year={2010},
  volume={8 12},
  pages={1601-9}
}
The cytokine/growth factor, macrophage migration inhibitory factor (MIF), contributes to pathologies associated with immune, inflammatory, and neoplastic disease processes. Several studies have shown an important contributing role for MIF-dependent COX-2 expression in the progression of these disorders. We now report that the MIF homologue, D-dopachrome tautomerase (D-DT), is both sufficient and necessary for maximal COX-2 expression in colorectal adenocarcinoma cell lines. D-DT-dependent COX-2… CONTINUE READING