The MHV 68 M 2 Protein Drives IL-10 Dependent B Cell Proliferation and Differentiation

@inproceedings{SiegelTheM6,
  title={The MHV 68 M 2 Protein Drives IL-10 Dependent B Cell Proliferation and Differentiation},
  author={Andrea M. Siegel and Jeremy H Herskowitz and Samuel H. Speck}
}
Murine gammaherpesvirus 68 (MHV68) establishes long-term latency in memory B cells similar to the human gammaherpesvirus Epstein Barr Virus (EBV). EBV encodes an interleukin-10 (IL-10) homolog and modulates cellular IL-10 expression; however, the role of IL-10 in the establishment and/or maintenance of chronic EBV infection remains unclear. Notably, MHV68 does not encode an IL-10 homolog, but virus infection has been shown to result in elevated serum IL-10 levels in wild-type mice, and IL-10… CONTINUE READING

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