The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.

  title={The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.},
  author={Qi Zhao and Dorina Saro and Aristidis Sachpatzidis and Thiyam Ramsing Singh and Daniel J Schlingman and Xiao-feng Zheng and Andrew H Mack and Miaw-sheue Tsai and Simon G. J. Mochrie and Lynne J Regan and Amom Ruhikanta Meetei and Patrick Sung and Yong Xiong},
  journal={Nature communications},
The conserved MHF1-MHF2 (MHF) complex functions in the activation of the Fanconi anaemia pathway of the DNA damage response, in regulating homologous recombination, and in DNA replication fork maintenance. MHF facilitates the processing of multiple types of branched DNAs by the DNA translocase FANCM. Here we report the crystal structure of a human MHF-DNA complex that reveals the DNA-binding mode of MHF. The structure suggests that MHF prefers branched DNA over double-stranded DNA because it… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
8 Citations
47 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 47 references

The structure of the FANCM-MHF complex reveals physical features for functional assembly

  • Y Tao
  • Nat. Commun
  • 2012

Similar Papers

Loading similar papers…