The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

@article{Zerrahn1997TheMR,
  title={The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection},
  author={J. Zerrahn and W. Held and D. Raulet},
  journal={Cell},
  year={1997},
  volume={88},
  pages={627-636}
}
T cell antigen receptors (TCRs) on mature T cells react with peptide antigens presented by self-MHC proteins and also frequently cross-react with foreign MHC proteins. The fundamental question whether MHC reactivity is inherent in the germline TCR sequences or is imposed by thymic selection was addressed here by inducing nonselective maturation of immature thymocytes in the absence of MHC molecules. MHC reactivity in the preselection repertoire is very high, but no higher than in the normal… Expand
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Background Citations
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In the normal repertoire of CD4+ T cells, a single class II MHC/peptide complex positively selects TCRs with various antigen specificities.
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Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules
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MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection.
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A quantitative theory of affinity-driven T cell repertoire selection.
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Role of thymic cortex-specific self-peptides in positive selection of T cells.
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Germline-encoded amino acids in the αβ T cell receptor control thymic selection
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The Intricate Behavior of T Cells
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