The METTL20 Homologue from Agrobacterium tumefaciens Is a Dual Specificity Protein-lysine Methyltransferase That Targets Ribosomal Protein L7/L12 and the β Subunit of Electron Transfer Flavoprotein (ETFβ)*

@article{Maecki2016TheMH,
  title={The METTL20 Homologue from Agrobacterium tumefaciens Is a Dual Specificity Protein-lysine Methyltransferase That Targets Ribosomal Protein L7/L12 and the $\beta$ Subunit of Electron Transfer Flavoprotein (ETF$\beta$)*},
  author={Jędrzej M. Małecki and Helge-Andr{\'e} Dahl and Anders Moen and Erna Davydova and P{\aa}l {\O}. Falnes},
  journal={The Journal of Biological Chemistry},
  year={2016},
  volume={291},
  pages={9581 - 9595}
}
Human METTL20 is a mitochondrial, lysine-specific methyltransferase that methylates the β-subunit of electron transfer flavoprotein (ETFβ). Interestingly, putative METTL20 orthologues are found in a subset of α-proteobacteria, including Agrobacterium tumefaciens. Using an activity-based approach, we identified in bacterial extracts two substrates of recombinant METTL20 from A. tumefaciens (AtMETTL20), namely ETFβ and the ribosomal protein RpL7/L12. We show that AtMETTL20, analogous to the human… 

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