The MDM2-p53 interaction.

  title={The MDM2-p53 interaction.},
  author={Ute M. Moll and Oleksi Petrenko},
  journal={Molecular cancer research : MCR},
  volume={1 14},
Activation of the p53 protein protects the organism against the propagation of cells that carry damaged DNA with potentially oncogenic mutations. MDM2, a p53-specific E3 ubiquitin ligase, is the principal cellular antagonist of p53, acting to limit the p53 growth-suppressive function in unstressed cells. In unstressed cells, MDM2 constantly… CONTINUE READING

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