The MCM-Binding Protein ETG1 Aids Sister Chromatid Cohesion Required for Postreplicative Homologous Recombination Repair

@inproceedings{Takahashi2010TheMP,
  title={The MCM-Binding Protein ETG1 Aids Sister Chromatid Cohesion Required for Postreplicative Homologous Recombination Repair},
  author={Naoki Takahashi and Mauricio Quimbaya and Veit Schubert and Tim Lammens and Klaas Vandepoele and Ingo Schubert and Minami Matsui and Dirk Inz{\'e} and Geert Berx and Lieven De Veylder},
  booktitle={PLoS genetics},
  year={2010}
}
The DNA replication process represents a source of DNA stress that causes potentially spontaneous genome damage. This effect might be strengthened by mutations in crucial replication factors, requiring the activation of DNA damage checkpoints to enable DNA repair before anaphase onset. Here, we demonstrate that depletion of the evolutionarily conserved minichromosome maintenance helicase-binding protein ETG1 of Arabidopsis thaliana resulted in a stringent late G2 cell cycle arrest. This arrest… CONTINUE READING

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