The MC1R melanoma risk variant p.R160W is associated with Parkinson disease.

  title={The MC1R melanoma risk variant p.R160W is associated with Parkinson disease.},
  author={Gemma Tell-Mart{\'i} and Joan Anton Puig-Butill{\'e} and Miriam Potrony and C{\'e}lia B{\'a}denas and Montserrat Mil{\`a} and Josep Malvehy and Maria Jose Marti and Mario Ezquerra and Rub{\'e}n Fern{\'a}ndez-Santiago and Susana Puig},
  journal={Annals of neurology},
  volume={77 5},
Epidemiological studies have reported the co-occurrence of Parkinson disease (PD) and melanoma. Common genetic variants in the MC1R (melanocortin 1 receptor) gene, which determines skin and hair color, are associated with melanoma. Here we investigated whether genetic variants in MC1R modulate the risk of PD by sequencing the entire gene in 870 PD patients and 736 controls ascertained from Spain. We found that the MC1R variant p.R160W (rs1805008) is marginally associated with PD (odds ratio = 2… CONTINUE READING
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