The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.

@article{Omote2006TheMP,
  title={The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.},
  author={Hiroshi Omote and Miki Hiasa and Takuya Matsumoto and Masato Otsuka and Yoshinori Moriyama},
  journal={Trends in pharmacological sciences},
  year={2006},
  volume={27 11},
  pages={587-93}
}
Multidrug and toxic compound extrusion (MATE) proteins, comprising the most recently designated family of multidrug transporter proteins, are widely distributed in all kingdoms of living organisms, although their function is far from understood. The bacterial MATE-type transporters that have been characterized function as exporters of cationic drugs, such as norfloxacin and ethidium, through H(+) or Na(+) exchange. Plant MATE-type transporters are involved in the detoxification of secondary… CONTINUE READING

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