The MAPK signaling cascade.

@article{Seger1995TheMS,
  title={The MAPK signaling cascade.},
  author={Rony Seger and Edwin G. Krebs},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1995},
  volume={9 9},
  pages={726-35}
}
The transmission of extracellular signals into their intracellular targets is mediated by a network of interacting proteins that regulate a large number of cellular processes. Cumulative efforts from many laboratories over the past decade have allowed the elucidation of one such signaling mechanism, which involves activations of several membranal signaling molecules followed by a sequential stimulation of several cytoplasmic protein kinases collectively known as mitogen-activated protein kinase… CONTINUE READING
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