The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch

@article{Sugiura1999TheMK,
  title={The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch},
  author={Reiko Sugiura and Takashi Toda and Susheela Dhut and Hisato Shuntoh and Takayoshi Kuno},
  journal={Nature},
  year={1999},
  volume={399},
  pages={479-483}
}
The mitogen-activated protein kinase (MAPK) pathway is a highlyconserved eukaryotic signalling cascade that converts extracellular signals into various outputs, such as cell growth and differentiation. MAPK is phosphorylated and activated by a specific MAPK kinase (MAPKK): MAPKK is therefore considered to be an activating regulator of MAPK. Pmk1 is a MAPK that regulates cell integrity and which, with calcineurin phosphatase, antagonizes chloride homeostasis in fission yeast. We have now… CONTINUE READING