The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes

Abstract

Regulation of gene expression by mitogen-activated protein kinases (MAPKs) is essential for proper cell adaptation to extracellular stimuli. Exposure of yeast cells to high osmolarity results in rapid activation of the MAPK Hog1, which coordinates the transcriptional programme required for cell survival on osmostress. The mechanisms by which Hog1 and MAPKs… (More)
DOI: 10.1038/nature02258

Topics

4 Figures and Tables