The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer

@article{Rey2016TheMZ,
  title={The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer},
  author={Christophe Rey and Benjamin Faustin and Isabelle Mahouche and Rosamaria Ruggieri and C{\'e}line Brulard and François Ichas and Isabelle Soubeyran and Lydia Lartigue and Francesca De Giorgi},
  journal={Oncogene},
  year={2016},
  volume={35},
  pages={3190-3200}
}
Often described as a mediator of cell cycle arrest or as a pro-apoptotic factor in stressful conditions, the MAP3K ZAK (Sterile alpha motif and leucine zipper-containing kinase) has also been proven to positively regulate epidermal growth factor receptor (EGFR) and WNT signaling pathways, cancer cell proliferation and cellular neoplastic transformation. Here, we show that both isoforms of ZAK, ZAK-α and ZAK-β are key factors in cancer cell migration. While ZAK depletion reduced cell motility of… CONTINUE READING
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