The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo.

@article{Fang2012TheMP,
  title={The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo.},
  author={Evandro Fei Fang and Chris Zhi Yi Zhang and Jack Ho Wong and Jia Yun Shen and Chuan Li and T. B. Ng},
  journal={Cancer letters},
  year={2012},
  volume={324 1},
  pages={66-74}
}
Human hepatocellular carcinoma Hep G2 cells and Hep G2-bearing mice were used as in vitro and in vivo models to assess the efficacy and safety of MAP30, a natural component from Momordica charantia, as an anticancer agent against liver cancer. Molecular studies disclosed the contribution of both caspase-8 regulated extrinsic and caspase-9 regulated intrinsic caspase cascades in MAP30-induced cell apoptosis. The antitumor potential was also effective in Hep G2-bearing nude mice. Since bitter… CONTINUE READING
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