The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions.

@article{Keshet2010TheMK,
  title={The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions.},
  author={Yonat Keshet and Rony Seger},
  journal={Methods in molecular biology},
  year={2010},
  volume={661},
  pages={3-38}
}
Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK) cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four MAPK cascades have been identified in the last 20 years and those are usually named according to the MAPK components that are the central building blocks of each of the cascades. These are the extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-Terminal kinase (JNK), p38, and ERK5 cascades. Each of these… CONTINUE READING

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