The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide.

@article{Wartmann1995TheMK,
  title={The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide.},
  author={Markus Wartmann and David G Campbell and Arul Subramanian and Sumner H Burstein and Roger J Davis},
  journal={FEBS letters},
  year={1995},
  volume={359 2-3},
  pages={133-6}
}
Anandamide is an endogenous ligand for delta 9-tetrahydrocannabinol (THC) receptors. Incubation of cultured cells with anandamide or THC causes increased arachidonic acid release and eicosanoid biosynthesis. Here we demonstrate that the MAP kinase signal transduction pathway contributes to this response. Treatment of WI-38 fibroblasts with anandamide causes increased MAP kinase activity and increased phosphorylation of the arachidonate-specific cytoplasmic phospholipase A2 (cPLA2… CONTINUE READING