[The MAP kianase cascade. A key target for treatments in skin cancerology].

Abstract

Intracellular mitogen-activated protein kinases (MAPK) form a signalling cascade of proteins involved in cell proliferation, differentiation, migration and apoptosis. They are particularly activated by some cytokines, hormones, environmental stress and in skin cancers as well. A series of pharmacological compounds targeting the MAPK cascade dramatically changes skin cancerology, at least during a transient phase of the metastatic process. Some combined treatments possibly increase the median overall survival.

Cite this paper

@article{Prard2013TheMK, title={[The MAP kianase cascade. A key target for treatments in skin cancerology].}, author={G. E. P{\'i}{\'e}rard and C Pi{\'e}rard-franchimont and B{\'e}n{\'e}dicte L{\'e}onard and Philippe Delvenne}, journal={Revue médicale de Liège}, year={2013}, volume={68 12}, pages={650-4} }