The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate.

Abstract

Mef2c is a MADS (MCM1-agamous-deficient serum response factor) transcription factor best known for its role in muscle and cardiovascular development. A causal role of up-regulated MEF2C expression in myelomonocytic acute myeloid leukemia (AML) has recently been demonstrated. Due to the pronounced monocytic component observed in Mef2c-induced AML, this study… (More)
DOI: 10.1182/blood-2007-10-116343

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