The MAD1 1673 G → A polymorphism alters the function of the mitotic spindle assembly checkpoint and is associated with a worse response to induction chemotherapy and sensitivity to treatment in patients with advanced epithelial ovarian cancer.

Abstract

BACKGROUND Mitotic arrest deficient 1 (MAD1), a protein of the mitotic spindle assembly checkpoint (SAC), recognizes MAD2 through two leucine zippers, transporting and activating MAD2, which promotes a metaphase arrest signal. A single nucleotide polymorphism of MAD1 was found to affect the SAC function that could be involved in a poor response to… (More)
DOI: 10.1097/FPC.0b013e32835ea08a

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@article{Santibanez2013TheM1, title={The MAD1 1673 G → A polymorphism alters the function of the mitotic spindle assembly checkpoint and is associated with a worse response to induction chemotherapy and sensitivity to treatment in patients with advanced epithelial ovarian cancer.}, author={Miguel Angel Soto Santibanez and Dolores Gallardo and Flavia Morales and Alejandro L{\'o}pez and Diddier Prada and Julia Mendoza and Clementina H Castro and David Cant{\'u} de Le{\'o}n and Luis F O{\~n}ate and Delia Perez and Alejandro Mohar and Luis A. Herrera}, journal={Pharmacogenetics and genomics}, year={2013}, volume={23 4}, pages={190-9} }