The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

@article{Hayashi1997TheMP,
  title={The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling},
  author={H. Hayashi and S. Abdollah and Yubin Qiu and Jiexing Cai and Yong-Yao Xu and B. Grinnell and M. Richardson and J. N. Topper and M. Gimbrone and J. Wrana and D. Falb},
  journal={Cell},
  year={1997},
  volume={89},
  pages={1165-1173}
}
Abstract TGFβ signaling is initiated when the type I receptor phosphorylates the MAD-related protein, Smad2, on C-terminal serine residues. This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses. Here we demonstrate that Smad7 is an inhibitor of TGFβ signaling. Smad7 prevents TGFβ-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2. Smad7 interacts stably with the activated TGFβ type I… Expand
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