The MACPF/CDC family of pore-forming toxins

@article{Rosado2008TheMF,
  title={The MACPF/CDC family of pore-forming toxins},
  author={Carlos J. Rosado and Stephanie C. Kondos and Tara E. Bull and Michael J. Kuiper and Ruby H P Law and Ashley M. Buckle and Ilia Voskoboinik and Phillip I Bird and Joseph Albert Trapani and James C. Whisstock and Michelle A. Dunstone},
  journal={Cellular Microbiology},
  year={2008},
  volume={10},
  pages={1765 - 1774}
}
Pore-forming toxins (PFTs) are commonly associated with bacterial pathogenesis. In eukaryotes, however, PFTs operate in the immune system or are deployed for attacking prey (e.g. venoms). This review focuses upon two families of globular protein PFTs: the cholesterol-dependent cytolysins (CDCs) and the membrane attack complex/perforin superfamily (MACPF). CDCs are produced by Gram-positive bacteria and lyse or permeabilize host cells or intracellular organelles during infection. In eukaryotes… CONTINUE READING

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