The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

@article{Christofk2008TheMS,
  title={The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth},
  author={H. Christofk and M. V. Heiden and M. Harris and A. Ramanathan and R. Gerszten and R. Wei and M. Fleming and S. Schreiber and L. Cantley},
  journal={Nature},
  year={2008},
  volume={452},
  pages={230-233}
}
  • H. Christofk, M. V. Heiden, +6 authors L. Cantley
  • Published 2008
  • Biology, Medicine
  • Nature
  • Many tumour cells have elevated rates of glucose uptake but reduced rates of oxidative phosphorylation. This persistence of high lactate production by tumours in the presence of oxygen, known as aerobic glycolysis, was first noted by Otto Warburg more than 75 yr ago. How tumour cells establish this altered metabolic phenotype and whether it is essential for tumorigenesis is as yet unknown. Here we show that a single switch in a splice isoform of the glycolytic enzyme pyruvate kinase is… CONTINUE READING
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