The M1 Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala.

@article{Miller2017TheMM,
  title={The M1 Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala.},
  author={Steven L Miller and Vassiliki Aroniadou-Anderjaska and Volodymyr I. Pidoplichko and Ta{\'i}za Helena Figueiredo and James P. Apland and Jishnu K. S. Krishnan and Maria Fatima de Melo Braga},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2017},
  volume={360 1},
  pages={23-32}
}
Exposure to organophosphorus toxins induces seizures that progress to status epilepticus (SE), which can cause brain damage or death. Seizures are generated by hyperstimulation of muscarinic receptors, subsequent to inhibition of acetylcholinesterase; this is followed by glutamatergic hyperactivity, which sustains and reinforces seizure activity. It has… CONTINUE READING