The M cell as a portal of entry to the lung for the bacterial pathogen Mycobacterium tuberculosis.

@article{Teitelbaum1999TheMC,
  title={The M cell as a portal of entry to the lung for the bacterial pathogen Mycobacterium tuberculosis.},
  author={Rachel Teitelbaum and Walter Schubert and Lukas Gunther and Yvonne Kress and Filippo Macaluso and Jeffrey W. Pollard and David Neil McMurray and Barry R. Bloom},
  journal={Immunity},
  year={1999},
  volume={10 6},
  pages={641-50}
}
M. tuberculosis accesses the terminal lung and is phagocytosed by alveolar macrophages. Utilizing a mouse intratracheal challenge model, we demonstrate that M. tuberculosis rapidly enters through M cells as well. From there, bacilli are deposited within associated intraepithelial leukocytes and subsequently conveyed to the draining lymph nodes early after… CONTINUE READING