The M-T hook structure is critical for design of HIV-1 fusion inhibitors.

  title={The M-T hook structure is critical for design of HIV-1 fusion inhibitors.},
  author={Huihui Chong and Xue Biao Yao and Jianping Sun and Zonglin Qiu and Meng Zhang and Sandro Waltersperger and Meitian Wang and Sheng Cui and Yuxian He},
  journal={The Journal of biological chemistry},
  volume={287 41},
CP621-652 is a potent HIV-1 fusion inhibitor peptide derived from the C-terminal heptad repeat of gp41. We recently identified that its N-terminal residues Met-626 and Thr-627 adopt a unique hook-like structure (termed M-T hook) thus stabilizing the interaction of the inhibitor with the deep pocket on the N-terminal heptad repeat. In this study, we further demonstrated that the M-T hook structure is a key determinant of CP621-652 in terms of its thermostability and anti-HIV activity. To… CONTINUE READING

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