The M-Maze task: An automated method for studying fear memory in rats exposed to protracted aversive conditioning

  title={The M-Maze task: An automated method for studying fear memory in rats exposed to protracted aversive conditioning},
  author={R. R. Souza and Nicole M. Robertson and David T. Pruitt and L. Noble and E. Meyers and Phillip A. Gonzales and Nathaniel P. Bleker and H. Carey and S. Hays and M. Kilgard and C. McIntyre and R. Rennaker},
  journal={Journal of Neuroscience Methods},
BACKGROUND Fear conditioning (FC) in rodents is the most used animal model to investigate the neurobiology of posttraumatic stress disorder (PTSD). Although research using FC has generated a better understanding of fear memories, studies often rely on mild or moderate FC training and behavioral analysis generally focuses on measuring freezing responses within few test sessions. NEW METHOD We introduce the M-Maze task, a system that measures extinction of conditioned fear using suppression of… Expand
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