The Lysosome as a Regulatory Hub.

  title={The Lysosome as a Regulatory Hub.},
  author={Rushika M. Perera and Roberto Zoncu},
  journal={Annual review of cell and developmental biology},
  • R. PereraR. Zoncu
  • Published 6 October 2016
  • Biology
  • Annual review of cell and developmental biology
The lysosome has long been viewed as the recycling center of the cell. However, recent discoveries have challenged this simple view and have established a central role of the lysosome in nutrient-dependent signal transduction. The degradative role of the lysosome and its newly discovered signaling functions are not in conflict but rather cooperate extensively to mediate fundamental cellular activities such as nutrient sensing, metabolic adaptation, and quality control of proteins and organelles… 

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