The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.

@article{Hsiou2001TheLM,
  title={The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.},
  author={Y. F. Hsiou and Jianping Ding and Kalyan Das and Arthur D. Clark and Paul L. Boyer and Paul Lewi and Paul A.J. Janssen and J P Kleim and Manfred Roesner and Stephen H. Hughes and Eddy Arnold},
  journal={Journal of molecular biology},
  year={2001},
  volume={309 2},
  pages={
          437-45
        }
}
Inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (RT) are widely used in the treatment of HIV infection. Loviride (an alpha-APA derivative) and HBY 097 (a quinoxaline derivative) are two potent non-nucleoside RT inhibitors (NNRTIs) that have been used in human clinical trials. A major problem for existing anti-retroviral therapy is the emergence of drug-resistant mutants with reduced susceptibility to the inhibitors. Amino acid residue 103 in the p66 subunit of HIV-1 RT is… CONTINUE READING

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