• DOI:10.1159/000071703
Corpus ID: 24829973

The Luteinizing Hormone Surge Is Preceded by an Estrogen-Induced Increase of Hypothalamic Progesterone in Ovariectomized and Adrenalectomized Rats

@article{Micevych2003TheLH,
  title={The Luteinizing Hormone Surge Is Preceded by an Estrogen-Induced Increase of Hypothalamic Progesterone in Ovariectomized and Adrenalectomized Rats},
  author={P. Micevych and K. Sinchak and R. Mills and L. Tao and P. Lapolt and J. Lu},
  journal={Neuroendocrinology},
  year={2003},
  volume={78},
  pages={29 - 35}
}

P. Micevych, K. Sinchak, +3 authors J. Lu

Published 2003

Biology, Medicine

Neuroendocrinology

As circulating estrogen levels rise on the afternoon of proestrus, they stimulate the hypothalamo-pituitary axis. This estrogen positive feedback is pivotal to stimulate the luteinizing hormone (LH) surge required for ovulation and luteinization of ovarian follicles. In addition to estrogen, pre-LH surge progesterone is critical for an LH surge as was demonstrated by blocking progesterone synthesis. In ovariectomized (OVX) rats treated with trilostane, a blocker of the enzyme 3β-hydroxysteroid… CONTINUE READING

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