The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction

@inproceedings{Kannan2013TheLP,
  title={The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction},
  author={Nagarajan Kannan and Nazmul Huda and LiRen Tu and Radina Droumeva and Geraldine Aubert and Elizabeth Chavez and Ryan Remy Brinkman and Peter M. Lansdorp and Joanne T. Emerman and Satoshi Abe and Connie J. Eaves and David P. Gilley},
  booktitle={Stem cell reports},
  year={2013}
}
Telomeres are essential for genomic integrity, but little is known about their regulation in the normal human mammary gland. We now demonstrate that a phenotypically defined cell population enriched in luminal progenitors (LPs) is characterized by unusually short telomeres independently of donor age. Furthermore, we find that multiple DNA damage response proteins colocalize with telomeres in >95% of LPs but in <5% of basal cells. Paradoxically, 25% of LPs are still capable of exhibiting robust… CONTINUE READING
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