The Lower Bound to the Evolution of Mutation Rates

@inproceedings{Lynch2011TheLB,
  title={The Lower Bound to the Evolution of Mutation Rates},
  author={Michael Lynch},
  booktitle={Genome biology and evolution},
  year={2011}
}
Despite substantial attention from theoreticians, the evolutionary mechanisms that drive intra- and interspecific variation in the mutation rate remain unclear. It has often been argued that mutation rates associated with the major replicative polymerases have been driven down to their physiological limits, defined as the point at which further enhancement in replication fidelity incurs a cost in terms of reproductive output, but no evidence in support of this argument has emerged for cellular… CONTINUE READING
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